How does CRISPR/Cas9 relate to real life for people with Down Syndrome? PLEASE ANSWER IN COMPLETE SENTENCES!!!!!! AND ANSWER IN ONE PARAGRAPH, PLEASEEE!!!!! WILL GIVE BRAINLIEST FOR COMPLETE ANSWER!!!

Answers

Answer 1

Answer:

Explanation:

The gene editing tool known as CRISPR-Cas9 could unintentionally damage DNA during the editing process or unintentionally edit regions that were not targeted. While these possibilities sound scary—and they could be—no one is in immediate harm.

Answer 2
Down syndrome (DS) is one of the most prevalent genetic disorders in humans. The use of new approaches in genetic engineering and nanotechnology methods in combination with natural cellular phenomenon can modify the disease in affected people. We consider two CRISPR/Cas9 systems to cut a specific region from short arm of the chromosome 21 (Chr21) and replace it with a novel designed DNA construct, containing the essential genes in chromatin remodeling for inactivating of an extra Chr21. This requires mimicking of the natural cellular pattern for inactivation of the extra X chromosome in females. By means of controlled dosage of an appropriate Nano-carrier (a surface engineered Poly D, L-lactide-co-glycolide (PLGA) for integrating the relevant construct in Trisomy21 brain cell culture media and then in DS mouse model, we would be able to evaluate the modification and the reduction of the active extra Chr21 and in turn reduce substantial adverse effects of the disease, like intellectual disabilities. The hypothesis and study seek new insights in Down syndrome modification.

Related Questions

Why do economists measure profit differently from accountants?

Answers

Accountants only concern themselves with direct costs which involve things like the cost of materials, rent, and labor for instance. This profit is aptly named "accounting profit".

Economists consider those costs as well, but they also include indirect costs such as opportunity costs of other investments. Recall that opportunity cost is the cost of what you give up if you make a certain decision.

For instance, if a car factory makes 4 door sedans, but it could be making more money with SUVs, then the opportunity cost is high and the economic profit is lower compared to the accounting profit.

explain why the distance between two meridians at the North Pole is 0 miles

Answers

La girl wa ke yo are
S

Answer:

This is because they intersect at the north pole

Explanation:

list all the pairs of vertical angles in the diagram ​

Answers

Answer:

hi! can you pls add an image of the diagram, otherwise I cant help

Using the phosphorus data from the table, calculate the percentage of each phosphorus source that enters the Mississippi from the city of St. Paul.

Answers

Answer/Explanation:

% of each Nitrogen source = amount of Nitrogen from each source/total amount if Nitrogen × 100

% of Nitrogen from atmospheric deposition:

[tex] \frac{1,300}{7,400}*100 = \frac{130,000}{7,400} = 17.57 [/tex]

Approximately 18%

% of Nitrogen from household pet waste:

[tex] \frac{2,100}{7,400}*100 = \frac{210,000}{7,400} = 28.38 [/tex]

Approximately 28%

% of Nitrogen from residential fertilizer:

[tex] \frac{3,800}{7,400}*100 = \frac{380,000}{7,400} = 51.35 [/tex]

Approximately 51%

% of Nitrogen from weathering:

0%

% of Nitrogen from county compost:

[tex] \frac{200}{7,400}*100 = \frac{20,000}{7,400} = 2.70 [/tex]

Approximately 3%

Who is the nice person in the worldk

Answers

Answer:

me

Explanation:

cause I care a d love everyone

Answer:

Me

Explanation:

I hope

Write a short speech that persuades students and parents to choose the bake-sale fundraiser instead of the car-wash fundraiser.

Remember to include a:

topic sentence that connects to the audience.
claim, reason, and evidence.
counterclaim and rebuttal.
call to action.
Write your speech in the space below:

Answers

Answer:

I think the bake sale would be better because, if one we're to do a car wash they may not know how to wash a car and selling baked goods is WAY easier than a car wash. A car wash can be bad depending on the weather and the bake sale. So I would chose the bake sale, it's easier, faster and much more.

Explanation:

want a short speech?

Answer:

Friends: What should we do to raise money? A bake sale will help us raise money for the local food bank because bake sales can attract people from outside the school community. The neighboring town was able to raise over $5,000 at their bake sale. Although the car wash is a good idea, people are more interested in buying homemade food. I strongly urge you to vote for the bake sale.

Explanation:

What is 2+2 multiplyed by 6-28+67?

Answers

Answer: 180

Explanation:
Answer: 180

Explanation:
2+2=4

PEMDAS: addition and subtraction from left to right so you would do 6-28 first then add 67.

6-28= -22
-22+67=45

4 X 45 = 180

What part of the brain allows Us to experience cocktail part effect

Answers

the auditory regions of the brain

from “A Talk to Teachers”
by James Baldwin
The word “myth” is used for all of the following purposes EXCEPT to
A.
emphasize the false logic to which many white Americans subscribe regarding African Americans
B.
serve as the foundation for his supporting evidence in this section
C.
establish ethos and show that Baldwin is an unbiased commentator
D.
suggest that white Americans have a childlike desire to believe false stories over harsh realities
E.
suggest that American history is not educational because most accounts have been mythologized

Answers

Answer:

C

Explanation:

Trust in me brother

e) 375 math problem​

Answers

Answer:

não há nada aqui!!!!!

Explanation:

What is the question

Maria notices that her paragraphs are to close to one another.

Answers

Answer:

Maria can change the spacing and indent. If the paragraphs are too close space and indent.

Explanation:

please help me please​

Answers

Answer:

4.A

5.A

6.B

7.A

8.A

Enjoy ❣️

The complete set of cases from which samples may be drawn is called a(n) A.control condition. B.independent variable. C.case study. D.population. E.survey.

Answers

Answer:

D. Population

Explanation:

Hope this helps lol.

The complete set of cases from which samples may be drawn is called as population. Thus option D is correct.

what is population ?

A population can be defined as complete group of individuals which  comprises a nation or a group of individuals having common characteristic features.

It is a pool of  individuals from which the statistical sample is drawn for a study purpose, so the election of individuals grouped by a common feature which can be called as population.

For, a statistical analysis of a sample of a population must report a standard deviation, or standard error,  so that the results from the entire population can be determined properly.

Thus option D is correct.

For more details regarding population, here

https://brainly.com/question/14417887

#SPJ2

How can teens model good physical fitness to other teens in their neighborhood?
O by reading books at the library
O by baking cookies for the elderly
O by riding their bikes to school
O by growing vegetables in their own gardens

Answers

Answer:

c

Explanation:

it's the only option that shows physical activity

The way in which teens can model good physical fitness to other teens in their neighborhood is: C. by riding their bikes to school.

What is physical fitness?

Physical fitness can be defined as a measure of both the physical and mental soundness (wellness) or ability of an individual to engage in physical exercises, sports, work and other day-to-day activities.

In this context, an example of a way in which teens can model good physical fitness to other teens in their neighborhood is by riding their bikes to school.

Read more on physical fitness here: brainly.com/question/1809216

#SPJ2

What are some consequences of globalization?

Answers

Well, global economic growth and industrial productivity are both the driving force and the major consequences of globalization. They also have big environmental consequences as they contribute to the depletion of natural resources, deforestation and the destruction of ecosystems and loss of biodiversity.

Answer:

Globalization sure does come with a lot of consequences. Some of them are:

(1) Globalization restricts the growth of local industries (especially in the case of textiles & automobiles) as the imported goods are cheaper than the local goods.

(2) It causes poor work conditions for the workers as they have to work for longer periods of time with less wages.

(3) Globalization also affects the economy & the countries that export goods earn more or have MNCs in other places than countries that import goods.

Hope it helps ⚜

FRQ Practice
Beth is walking to math class. She is feeling stressed about her big test. As she walks to class, she talks
with her friend Ted. When Beth arrives at class, the room is warm and she drinks some water to cool
off.
For each term listed below, identify its function as it relates to the above situation.
• Motor Neurons
• Sympathetic Nervous System
• Adrenal glands
Broca's Area
• Hypothalamus
-Cerebellum

Answers

Answer:  Adrenal glands

Explanation:

Adrenal glands are located above each human kidneys these glands secrete hormone adrenaline during stress conditions or during emergency.

Here, Beth is stressed about her test so she finds her classroom warm and an urge for thirst has also arise due to her being this is a kind of stress response generated by the adrenal glands and their secretions in the form of adrenaline hormone.  

“Gettysburg Address”
by Abraham Lincoln

Which of the following basic sentence types appear in the passage?

I. interrogative
II. imperative
III. declarative
A.
II only
B.
III only
C.
I and III
D.
II and III
E.
I, II, and III

Answers

Answer:

D.  II and III

Explanation:

Interrogative phrases are those that present a type of questioning, a type of question. In “Gettysburg Address,” Lincoln makes no question and for that reason, we can say that there are no interrogative phrases in the speech.

Almost every discourse contains declarative sentences that are phrases where the author finds a fact. Lincoln uses this type of phrase right at the beginning of the discreet, when he states that "87 years ago, our parents gave birth, on this continent, to a new Nation, conceived in Liberty and devoted to the principle that all men are born equal."

Lincoln also uses imperative phrases that are phrases used to express a request, an order or an instruction. It is possible to see these phrases at the very end of the speech when Lincoln says "It is up to us, the living, to dedicate ourselves today to the work unfinished up to this point so remarkably advanced by those who fought here."

Which of the following originated in China and spread via the Silk Roads?
law codes
algebra
papermaking
surgical techniques

Answers

Answer:

Papermaking

Explanation:

Paper was invented in China during the 3rd century B.C., and its use spread via the Silk Road, arriving first in Samarkand in around 700 A.D., before moving to Europe through the then-Islamic ports of Sicily and Spain

Papermaking. Paper-making technique which was invented by Cai Lun was delivered to the west through the Silk Road

PLEASE HELP ASAP!!
I WILL GIVE BRAINLIEST!!!

The table shows the electron negativity values of various elements on the periodic table. Which pair of elements would form an ionic bond?

A) carbon (c) and oxygen (o)
B) strontium (Sr) and chlorine (Cl)
C) cesium (Cs) and geranium (Ge)
D) magnesium (Mg) and aluminum (Al)

Answers

Answer: B

Explanation: Strontium lies in alkaline group so the valency is +2 and has 2 electrons in its valence shell. ... Therefore, electrons are transferred from chlorine to strontium. So ionic bond is formed.

URGENT!! Please Help ASAP!! 48 Points!! Assignment due in 15 minutes!!
Reflect on the questions below.

1.) Why do some people resist help from others?
2.) Is it useful to work separately at some point in time during pair programming?
3.) How is pair programming beneficial?
4.) In pair programming, how can we better work together?

Answers

Answer:

1. People have a hard to learn from others.

2. Yes, it is very helpful because one can code while the other navigate

3. Getting help can increse the chance of not missing something important

4. Communicate with each other

Explain why the mediation process laid out is so complicated?

Answers

Answer:

Mediation is much less formal than going to court, but the conflict resolution process does involve distinct stages designed to lead to a mutually beneficial compromise.

Explanation:

Unlike a judge or an arbitrator, the mediator won’t decide the outcome of the case. The mediator's job is to help the disputants resolve the problem through a process that encourages each side to:

=air disputes

=identify the strengths and weaknesses of their case

=understand that accepting less than expected is the hallmark of a fair settlement, and

=agree on a satisfactory solution.

Is this the country that our founding father Envisioned?

Answers

definitely not. Our country has become unconstitutional

What would you do if a Karen threatened take your skateboard and call the cops on you
Give me a meme answer or somthing halarious

Answers

Answer:

THROW THE SKATEBOARD AT HER AND RUNNNN, also if she records you and your a minor you can get her arrested cause recording a minor without their consent is illegal

Explanation:

:D

She would say let me speak to the manager first. I would say, I am the manager

Which fraction is less than the fraction represented by the model?

A circle divided into 8 equal parts. 5 parts are shaded.

Three-fourths
StartFraction 11 Over 16 EndFraction
StartFraction 13 Over 16 EndFraction
StartFraction 2 Over 4 EndFraction

Answers

Answer:

2/4

Explanation:

1/2 of the circle is less than what is shaded

Answer:

2/4

Explanation:

Explain the role that hereditary plays in skill-related fitness

Answers

Answer:

Heredity controls some aspects of inborn skill-related fitness and is described as natural ability. While these inherited traits have an impact on skill-related fitness, the extent of their influence is difficult to measure.

Explanation:

similarities between the ecomienda and slavery in the Spanish colonies ​

Answers

encomienda system posed a requirement of a group of individuals to give back to another in work, kind or otherwise, in exchange for a good received. It was established that a person who received the legal right to be an encomendero, had at his disposal a village of Indians with his caciques to pay him tribute and to serve him. In return, the Indians received "protection", that is to say, the encomendero had to take care of the well-being of the natives in the spiritual and in the earthly thing, assuring its maintenance and its protection, as well as its Christian indoctrination (evangelization).
The figure of the cacique or main character of the towns was very important because he used to be the intermediary between the encomendero and the Indians. The population was supposed to pay the Crown so the caciques collected the valuable things from their population and gave them to the encomendero.
This system differs from slavery inasmuch as it is considered as a system of exchanges where both parties give something in exchange for receiving something, in slavery there is no guarantee of anything to people, and they are only subjected to doing things for the sake of force. However, the encomienda has resembled slavery or has derived in it, since there have been abuses where forced labor, mistreatment and other things to the indigenous people ended up being imposed. On the other hand, encomienda as well as slavery is a system imposed. Another similarity is that the natives had to serve the encomendero, his family or whom they wanted to serve, in a mandatory manner. Also, both in the system of entrustment as in slavery, the people subjected do not have liberties, in the system of encomiendas you do not have the freedom to choose not to pay the crown since it is established as a duty and obligation, as well as they lose their freedom by being under the orders of the encomendero. In slavery, people also can not choose and must follow orders. But it should be mentioned that in the encomienda Indians could be entrusted for a maximum of 2 years, could not establish a perpetuity as dictated by the crown, different from the people subjected to slavery that were considered a more "economic" labor, they were forced to perform tasks under someone's command for indefinite periods, that is, there was a perpetuity of slavery that lasted as long as the person submitting them wanted, since in slavery one person (the master) takes over another ( the slave).

why do people call people 8 years old when that is not their age

Answers

be people are ignorant
Because people do not have enough words in their vocabulary to insult someone correctly, making them in fact the 8 year old.

What are the pros and cons of having high levels of phosphorus in soil from added fertilizers?

Answers

A pro is increased crop production and a con is injury to the seedlings which is caused when salts in fertilizer is more than the salts in the plant cells

I hope this helps:D

team Edward or team Jacob

I'm team Jacob so don't even

Answers

Answer:

Edward

Explanation:

because vampires are cooler than furries :/

Answer: Team Jacob

Explanation: The relationship between Bella and Edward is 100 percent toxic, unhealthy and abusive.Edward is overprotective and tries to restrict Bella's friend group, especially when she starts hanging out with Jacob Black and the other werewolves.Jacob is hotter than Edward. Jacob even says so. Bella's freezing in a tent and only Jacob's body temperature can keep her warm. When Patterson  heard Lautner say, "I'm hotter than you,".

A forest has a NPP of 2.8 kgC/m2/year and the rate of cellular respiration is 4.8 kgC/m2/year. What is the GPP?

Answers

The net primary productivity of an ecosystem is 1 kgC/ m2/year, and the energy needed by the producers for their own respiration is 1.5 kgC/m2/year.
Other Questions
Instructions:Take a minute to really study Ferdinand-Victor-Eugene Delacroixs Horses Coming Out of the Sea. When writing your visual analysis remember to discuss the subjects and themes, as well as discussing what you see in the foreground, middleground and background.Within the first part of your image analysis make sure to introduce the artist and title of the artwork, then describe whats taking place within the image. Use the concepts we recently learned about to help break down the image itself. (Its easier to say what objects you see and where you see them when you can refer to the different sections of an image.)In the second part of your image analysis I want you to think of the narrative thats taking place. (Whats happening in the image? What are the feelings that you feel are occuring in the image?) Then tell me your own feelings on this particular painting. Think of the following questions while you write:What all do you see within the painting, and where?What is happening in the painting? (Whats the narrative?)What are your thoughts on this particular piece? Question OneThere are 7 linomen, 2 running backs, 1 fullback, and 1 quarterback on an American football team. What is the ratio, in simplest form,of the number of linemen to the total number of players on the team?A1:2B.2:77:1111:2Question Two a=b=c=d=e=f=g=h=i=j=? PLZ HELP ME FAST IM GIVING BRAINLY TO WHOEVER HELPS ASAPRead the poem. Song of the Open Road by Walt Whitman Afoot and light-hearted, I take to the open road, Healthy, free, the world before me, The long brown path before me, leading wherever I choose. Henceforth I ask not good-fortuneI myself am good-fortune; Henceforth I whimper no more, postpone no more, need nothing, Strong and content, I travel the open road. . . . From this hour, freedom! From this hour I ordain myself loosd of limits and imaginary lines, Going where I list, my own master, total and absolute, Listening to others, and considering well what they say, Pausing, searching, receiving, contemplating, Gently, but with undeniable will, divesting myself of the holds that would hold me. I inhale great draughts of space; The east and the west are mine, and the north and the south are mine. I am larger, better than I thought; I did not know I held so much goodness. All seems beautiful to me; I can repeat over to men and women, You have done such good to me, I would do the same to you. I will recruit for myself and you as I go; I will scatter myself among men and women as I go; I will toss the new gladness and roughness among them; Whoever denies me, it shall not trouble me; Whoever accepts me, he or she shall be blessed, and shall bless me. Question 1 Part A What is a theme of "Song of the Open Road"? Travel allows one to connect with and feel the fellowship of others. Travel gives one a chance to realize the beauty and safety of home. Travels forces one to question oneself and others. Travel demands that one use caution and common sense. Question 2 Part B Which two quotes from the poem best help Whitman develop the theme identified in Part A? "I can repeat over to men and women, You have done such good to me, I would do the same to you." "I inhale great draughts of space; / The east and the west are mine, and the north and the south are mine." "Whoever accepts me, he or she shall be blessed, and shall bless me." "Henceforth I ask not good-fortuneI myself am good-fortune; / Henceforth I whimper no more, postpone no more, need nothing," ............................................................... student is training 4 a track team during the first 3 months of the year by running 30 minutes every day, while averaging 5 miles each day. Select graph that correctly shows the total miles ran during the time of training program if there is a sample 50 grams of naoh how many grams are na Find the slope of the line that passes through (4,8) and (2, 1)Please help What do you do with a book? Kuroo Performance art is usually: a. objective c. controversial b. colorful d. funny Find the value of |-9 + 1| - 4(4).-36-6-816I will make you brainlliest and give you some points. The Madison's son Dwayne GIVING BRAINLIEST!!!!How many solutions exist for the given equation?1/2(x+12)=4x-1 (1/2 is one half)zeroonetwoinfinitely many Raj is playing a game . He needs to find pairs of cards that have the same value . Which two pairs of cards does Raj have that express the same value? Please help me with physics homework I just need help with C and D. Picture is included Find the simple interest paid on a loan of $750 with an 18% rate over 2 years. This graph compares the cost of an education at different institutions in Texas.A graph titled The Cost of Tuition in Texas from 2012 to 2013 has type of school on the x-axis, and yearly cost in thousands of dollars on the y-axis. Public 4-year university is about 7,000, and private 4-year is 23,000. Public community college is 2,000, and private community college is 9,000. Technical school is 4,000.This graph demonstrates thatprivate universities can cost three times as much to attend as public universities.public universities can cost three times as much to attend as private universities.community colleges can cost five times as much to attend as technical schools.technical schools can cost five times as much to attend as community colleges. Hal wonders about the properties of electromagnetic waves that make up the visible light spectrum. He conducts an experiment to see how sunlight behaves while moving through a prism. He is able to separate visible light into colors of the rainbow. He notices that each color has a unique wavelength and frequency.Diagram showing wavelengths of light that make up the visible spectrum.Which of these statements describe visible light waves? Choose the two that apply.A.Red light has a longer distance between wave crests than blue light.B.Yellow light has a shorter distance between wave crests than green light.C.Blue light has a longer distance between wave crests than red light.D.Blue light has a shorter distance between wave crests than orange light.E.Orange light has a shorter distance between wave crests than violet light. How was the tone Benjamin Franklin used in the speech in the convention and what are his initial and final thoughts? illustrate the respiratory system